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Mediterranean Diet May Lower Risk of Brain Damage That Causes Thinking Problems

 
ScienceDaily (Feb. 9, 2010) — A Mediterranean diet may help people avoid the small areas of brain damage that can lead to problems with thinking and memory, according to a study that will be presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto April 10 to April 17, 2010.
 

The study found that people who ate a Mediterranean-like diet were less likely to have brain infarcts, or small areas of dead tissue linked to thinking problems.

The Mediterranean diet includes high intake of vegetables, legumes, fruits, cereals, fish and monounsaturated fatty acids such as olive oil; low intake of saturated fatty acids, dairy products, meat and poultry; and mild to moderate amounts of alcohol.

For the study, researchers assessed the diets of 712 people in New York and divided them into three groups based on how closely they were following the Mediterranean diet. Then they conducted MRI brain scans of the people an average of six years later. A total of 238 people had at least one area of brain damage.

Those who were most closely following a Mediterranean-like diet were 36 percent less likely to have areas of brain damage than those who were least following the diet. Those moderately following the diet were 21 percent less likely to have brain damage than the lowest group.

"The relationship between this type of brain damage and the Mediterranean diet was comparable with that of high blood pressure," said study author Nikolaos Scarmeas, MD, MSc, of Columbia University Medical Center in New York and a member of the American Academy of Neurology. "In this study, not eating a Mediterranean-like diet had about the same effect on the brain as having high blood pressure."

Previous research by Scarmeas and his colleagues showed that a Mediterranean-like diet may be associated with a lower risk of Alzheimer's disease and may lengthen survival in people with Alzheimer's disease. According to the present study, these associations may be partially explained by fewer brain infarcts.

The study was supported by the National Institutes of Health.

 
 
 
 

Mediterranean Diet Associated With Reduced Risk Of Alzheimer's Disease

 

ScienceDaily (Oct. 12, 2006) — Eating a Mediterranean diet, which emphasizes fruits, vegetables and olive oil and includes little red meat, is associated with a lower risk for Alzheimer's disease, according to an article posted online today that will appear in the December 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals. This association persisted even when researchers considered whether individuals had vascular diseases--diseases of the blood vessels, such as stroke, heart disease and diabetes--suggesting that the diet may work through different pathways to reduce Alzheimer's disease risk.
 

The Mediterranean diet consists of high amounts of fruits, vegetables, legumes, cereals and fish, mild to moderate amounts of alcohol and low amounts of red meat and dairy products, according to background information in the article. This diet has been associated with a lower risk for several diseases and risk factors, including cancer, obesity, high cholesterol, high blood pressure, problems with processing glucose that may lead to diabetes, coronary heart disease and overall death.

Nikolaos Scarmeas, M.D., and colleagues at Columbia University Medical Center, New York, studied whether the Mediterranean diet could also help prevent Alzheimer's disease--a debilitating neurodegenerative disease--in a group of 1,984 adults with an average age of 76.3. The participants, 194 of whom already had Alzheimer's disease and 1,790 of whom did not, were given complete physical and neurological examinations and a series of tests of brain function. Their diet over the previous year was analyzed and scored based on how closely it adhered to the principles of the Mediterranean diet--scores ranged from zero to nine, with higher scores indicating eating patterns that aligned closely with the Mediterranean diet. The researchers obtained information about vascular disease diagnoses from the exams, participants' or relatives' reports and medical records.

Eating a diet that closely followed the Mediterranean model was associated with a significantly lower risk for Alzheimer's disease. For each additional unit on the diet score, risk for Alzheimer's disease decreased by 19 to 24 percent. After the researchers considered other factors that could influence Alzheimer's disease risk, including age and body mass index, those who were in the top one-third of the diet scores had 68 percent lower odds of having Alzheimer's disease than those in the bottom one-third, and those in the middle-one third had 53 percent lower odds.

Growing evidence links the Mediterranean diet to a reduced risk for vascular disease and suggests that vascular risk factors may contribute to the risk for Alzheimer's disease, the authors write. "Thus, vascular variables are likely to be in the causal pathway between the Mediterranean diet and Alzheimer's disease and should be considered as possible mediators," they continue. "However, when we considered vascular risk factors in our models, the association between the Mediterranean diet and Alzheimer's disease did not change. This was the case despite our attempt to capture vascular comorbidity in the most complete possible way by simultaneously considering both a long list and alternative definitions of vascular variables."

"This could be the result of either other biological mechanisms (oxidative or inflammatory) being implicated or measurement error of the vascular variables," the authors conclude.